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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in older adults with a body mass index (BMI) of more than 27, provided that they also are afflicted by weight-related health issues such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure levels).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so when an aid to quitting smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle including a reduced-calorie diet and exercise, Contrave provides another treatment option for chronic weight loss for people who are obese or are overweight and have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercising. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of four.1% instead of participants who have been given placebos) within a 12- month period, while a different study involving patients with diabetes type 2 symptoms had the average weight loss of 2% over treatment with placebo at one year.

    Using two separate drugs to lose weight can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people that go through it you ought to err along the side of caution and permit the FDA do its job and demand some investigation be done in order that the public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies come in business to generate income and that they would say everything to keep people on the medications.

    Researchers found out that participants taking this drug to get a year, dropped a few pounds within one month and have kept the load off during the entire 56 weeks with the study. Contrave is a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which might be made up of more than one active ingredient, which can make them more efficient and safer.

    Combo-pilling may be the newest fad or also the newest to come under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that at the time of right now there aren't any long term prescription diet pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA.

    Seizures are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug can also raise blood pressure levels and heart rate, and must not be used in those with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not used in patients with uncontrolled high blood pressure level, along with by you are not heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients which has a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients for the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

    To keep up with essentially the most current articles from Wendi, the Indiana Addiction Recovery Examiner, click on the subscribe link at the top of the page for email notification when new articles are published. Please leave a comment for virtually any article.